Company releases its Supplement Facts, sales record, and a study-by-study comparison with published research on L-arginine and L-citrulline, and states that no trial has tested the finished capsule
LARGO, Fla., October 23, 2026 – Hema Balance has sold 917,800 bottles of its Blood Optimizer capsule over 24 months, with a reported 6.5% refund rate, according to company records released today. The company also published a study-by-study comparison of its 500 milligram proprietary blend with the published research on the individual ingredients in the capsule.
According to Hema Balance records, the bottles were sold to 218,750 verified customers. The company reported a 6.5% refund rate over the 90 days ending September 2026, and 28% of customers eligible to reorder did so within 90 days, measured through June 2026.
Hema Balance Sales Channel: Official Website
One capsule contains a proprietary blend of L-arginine HCl, L-arginine alpha-ketoglutarate, and L-citrulline malate. The blend weighs 500 milligrams per capsule. The label does not state how much of each compound it contains. The company states that no clinical trial has evaluated the finished capsule.
“People should be able to tell what is printed on a supplement label from what was tested in published research,” said Kevin Moore, Product Head at Hema Balance. “The blend total is disclosed. The amount of each ingredient is not, and the studies we reviewed used different forms, doses, and participants.”
What the Current Label Discloses
The Supplement Facts panel lists a proprietary blend of three amino-acid compounds: L-arginine HCl, L-arginine alpha-ketoglutarate, and L-citrulline malate. Other listed ingredients include gelatin (the capsule shell), rice flour, and magnesium stearate. One bottle contains 60 capsules.
The label directs adults to take one capsule daily with eight ounces of water and allows up to two capsules daily. At the highest labeled serving, the whole proprietary blend totals 1,000 milligrams, or 1 gram.
A proprietary blend states the combined weight of a formulation and leaves the amount of each ingredient undisclosed. A consumer can see the total for all three compounds but cannot calculate the exact amount of any one of them. That limit matters when comparing the capsule with research, because a study of a specific amount of L-arginine cannot be matched to a blend whose L-arginine content is unknown. The same is true for citrulline.
Company-Reported Sales Data
Hema Balance published the following figures from its own records. None were audited by an outside party.
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Bottles sold: 917,800, across 24 months on the market.
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Verified customers: 218,750, each order tied to a fulfillment record.
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Refund rate: 6.5% over the 90 days ending September 2026.
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Reorder rate: 28% of eligible customers within 90 days, measured through June 2026.
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Guarantee: 90 days, covering official orders only.
The company said the figures describe purchases, returns, and reorders. It said they are not evidence of any health effect.
Similar-Name and Duplicate Listings
Searching for the Hema Balance Blood Optimizer or for a blood optimizer supplement returns a mix of results, and not all of them describe this product. During September 2026, Hema Balance reviewed 538 online listings and pages that use the Hema Balance name or a close variant. Of those, some could be traced to official sales, others used the name without a trace to official sales, a portion were separate products with different formulas, and others repeated older ingredient descriptions that do not match the current label.
Hema Balance said it cannot tell from a listing alone whether a bottle is a resold genuine product or a copy. Any bottle bought outside official channels is outside its lot tracing and its guarantee. No seller is alleged to have committed any offense. The report describes listings that Hema Balance considers unauthorized under its sales policy and marketplace rules.
Similar names are a risk with proprietary blends, because a small change in formula can make an older ingredient description inaccurate. The company said buyers can compare the lot number printed on the bottle with the verification page on its official website, and can check any product description against the Supplement Facts panel on the current package.
Different Forms of Arginine and Citrulline
The three compounds in the blend are related but not interchangeable. L-arginine HCl is a salt form of the amino acid arginine. L-arginine alpha-ketoglutarate combines arginine with alpha-ketoglutarate, a compound involved in metabolic processes. L-citrulline malate combines citrulline with malate. The body can convert citrulline into arginine through normal metabolic pathways.
Research on one form does not establish the effects of another. Chemical form, dose, duration, and study population all affect whether two findings can be compared. For that reason, Hema Balance said the presence of an ingredient name on its label should not be read as evidence that the capsule produces the outcomes seen in studies of that ingredient.
Gram-Level Research and a 500 Milligram Blend
The clearest gap between the label and the research is the unit. The blend is measured in milligrams. The studies reviewed by the company mostly measured individual ingredients in grams per day.
At two capsules, the complete blend is 1 gram. If the entire blend were a single ingredient, the highest labeled serving would still be below the amounts used in many of the cited studies. The blend contains three ingredients, so the real amount of any one is smaller and unknown.
This does not show that the capsule works or fails to work. It shows that the amounts and formulations in the published research differ materially from the disclosed total weight of this product.
Published Research on L-Arginine
A 2011 meta-analysis in the American Heart Journal (Dong and colleagues) pooled randomized trials of oral L-arginine and blood pressure. It included 11 trials and 383 participants. The pooled results showed average reductions of about 5 mmHg in systolic and about 3 mmHg in diastolic blood pressure. The doses in those trials ranged from about 4 grams to 24 grams of L-arginine per day. The trials were small and short.
Those amounts are far above the total weight of one Hema Balance capsule. Because the company does not disclose how much L-arginine is in the blend, the trial results cannot be assumed to apply to the finished capsule.
Research That Also Raises Safety Questions
Arginine research has not been uniformly positive. A 2006 randomized trial in JAMA (the VINTAGE MI trial, Schulman and colleagues) gave L-arginine alongside standard care to about 150 people after a heart attack. The researchers did not find improvement in the vascular measurements studied. The trial was stopped after more deaths occurred in the arginine group than in the placebo group, and the investigators did not recommend L-arginine for that population.
That trial involved a specific patient group and should not be generalized to all adults. It does show why supplement research has to be read according to the people studied, the dose, and the medical circumstances. Hema Balance advises people with cardiovascular conditions to consult a qualified health care professional before using any amino-acid supplement.
Published Research on L-Citrulline
A 2019 systematic review and meta-analysis in the Avicenna Journal of Phytomedicine (Barkhidarian and colleagues) evaluated trials of L-citrulline supplementation and blood pressure. The pooled analysis reported a small reduction in systolic blood pressure. The individual studies were small and differed in participants, duration, and dose.
The review looked at citrulline supplementation in general. It did not evaluate Hema Balance or its combination of ingredients. Because the label does not state the amount of L-citrulline malate per capsule, the published doses cannot be matched to the product.
Citrulline Malate and Exercise Research
Some citrulline malate research concerns exercise and not blood pressure. A 2010 study in the Journal of Strength and Conditioning Research (Pérez-Guisado and Jakeman) gave a single 8 gram dose of citrulline malate to 41 men before resistance exercise. The researchers reported differences in repetitions completed and in muscle soreness afterward.
That study measured exercise performance, not treatment of any cardiovascular condition. The 8 gram dose is many times the entire 500 milligram blend in one capsule. The study describes one dose of one compound under specific exercise conditions and is not evidence about Hema Balance.
Research on L-Arginine Alpha-Ketoglutarate
Arginine alpha-ketoglutarate has also been studied in exercise settings. A 2006 trial in Nutrition (Campbell and colleagues) gave trained adult men about 12 grams per day of L-arginine alpha-ketoglutarate for eight weeks. The researchers reported differences in some strength and power measurements.
The study did not examine blood pressure and did not test the Hema Balance formulation. The daily amount was many times the complete daily blend listed on the label.
Ingredient Evidence Is Not Finished-Product Evidence
The company’s position is that research on an individual ingredient should not be presented as research on a finished multi-ingredient product. Several factors prevent a direct comparison: ingredient amount, chemical form, manufacturing method, participant health, length of use, and the outcome measured. A study may involve one ingredient while a commercial supplement contains several.
In this case, three compounds sit inside one proprietary blend with no individual amounts disclosed, and no published trial has tested the finished formulation. Hema Balance therefore does not claim that its capsule lowers blood pressure, treats hypertension, or produces the results reported in the individual studies. The words “Blood Optimizer” are part of the product’s name and are not a statement about what it does.
Blood Pressure Should Be Measured
High blood pressure often has no noticeable symptoms, so how a person feels is not a reliable guide. Clinical guidelines, including the 2017 ACC/AHA guideline, call for measuring blood pressure and, where appropriate, confirming readings outside a medical office. Treatment decisions can include lifestyle changes, medication, or both, depending on cardiovascular risk and readings.
Hema Balance states that no one should stop, reduce, skip, or change prescribed blood-pressure medication because they began a dietary supplement. Any change should be discussed with the prescribing health care professional.
Medication and Health Considerations
Arginine and citrulline may be relevant for people who use medicines that affect blood pressure or circulation. The company advises anyone taking blood-pressure medicines, nitrate medicines, blood thinners, diabetes medicines, or other prescriptions to speak with a qualified health care professional before using the product. The same advice applies to people with heart disease, kidney conditions, or a history of heart attack.
People preparing for surgery should tell their medical team about every supplement they use. The company also advises people who are pregnant, nursing, or under 18 not to use the product without appropriate medical guidance.
FDA Regulation and Supplement Labels
The U.S. Food and Drug Administration does not approve dietary supplements for safety and effectiveness before they are marketed, as it does for prescription drugs. A statement that a product is made in a facility following Good Manufacturing Practice requirements describes the facility. It does not mean the finished supplement is FDA-approved. An ingredient appearing in scientific literature is likewise not an approval of any commercial product that contains it.
Limitations
All sales, refund, reorder, and listing figures in this release come from Hema Balance records and were not independently audited. Listing counts reflect one month and change over time. A listing alone cannot show whether a bottle is genuine or a copy. The cited studies describe individual ingredients, mostly at gram-level amounts, in specific populations, and none of them tested the Hema Balance capsule. Individual amounts inside the blend are not disclosed, so no dose comparison can be made. The VINTAGE MI trial involved people after a heart attack and is reported here as safety context, not as a finding about all adults. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease and should not replace prescribed medication or professional medical care.
References
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Whelton PK, et al. 2017 ACC/AHA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Journal of the American College of Cardiology, 2018.
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Dong JY, et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. American Heart Journal, 2011.
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Schulman SP, et al. L-arginine therapy in acute myocardial infarction: the VINTAGE MI randomized clinical trial. JAMA, 2006.
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Barkhidarian B, et al. Effects of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis. Avicenna Journal of Phytomedicine, 2019.
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Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of Strength and Conditioning Research, 2010.
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Campbell B, et al. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition, 2006.
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MedlinePlus, U.S. National Library of Medicine. Arginine.
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U.S. Food and Drug Administration. Dietary Supplement Labeling Guide.
About Hema Balance
Hema Balance is a Largo, Florida-based dietary supplement company. Its Blood Optimizer capsule contains a proprietary blend of L-arginine HCl, L-arginine alpha-ketoglutarate, and L-citrulline malate, listed at 500 milligrams per capsule, with 60 capsules per bottle. The product is sold through the company’s official website.
Media Contact
Kevin Moore, Media Relations, Hema Balance
11870, 62nd St N, Largo, FL 33773
Email: support@myhemarenew.online
Website: myhemarenew.online
